Preheat your oven to 400°F (200°C).
Season the tilapia fillets generously with salt, black pepper, paprika, thyme, and oregano. Arrange them in a 9x13 baking dish.
In a mixing bowl, whisk together melted butter, minced garlic, lemon juice, and lemon zest until well combined.
Pour the garlic butter mixture over the seasoned tilapia fillets in the baking dish. Bake for about 10 to 12 minutes or until the fish flakes easily with a fork.
Garnish with red pepper flakes, chopped parsley, and fresh lemon slices before serving.